I have been using the ASUS Wireless Mouse MD105 for work and general day-to-day use, and its biggest strength is how straightforward it is.
It does not chase a long list of features that sound good on a spec sheet but rarely make a meaningful difference. Instead, ASUS has focused on the basics that matter in a daily-use mouse: a comfortable shape, dependable wireless connectivity, quiet clicks and the ability to work across multiple computers.
I used the MD105 in two different setups during my time with it. Connected to my MacBook over Bluetooth, it kept a USB port free, which is always useful on a laptop. I also paired it with a Windows machine using the bundled 2.4GHz wireless receiver. That gave me a good sense of how easily it fits into a two-device workflow.
This is clearly a productivity-focused mouse, not one built for gaming. It has a right-handed ergonomic shape, a thumb rest, two side buttons and an optical sensor with three DPI settings: 1,200, 1,600 and 2,400. It can also connect to up to three devices through Bluetooth and 2.4GHz wireless.
After using it across both machines, the MD105 feels like a sensible option for anyone who wants a comfortable, uncomplicated wireless mouse for work, browsing and everyday computing.
Asus Wireless Mouse MD105: Design and Build Quality
The ASUS MD105 does not follow the ultra-flat design usually associated with portable wireless mice. Instead, it uses a conventional ergonomic shape with a raised body, built-in thumb support and a profile designed primarily for right-handed users. It measures 110 × 72 × 43mm and weighs 66g without the battery.
That fuller shape is the point. If you spend hours browsing, writing documents, preparing presentations, editing spreadsheets or constantly switching between applications, a mouse that supports your palm properly makes far more sense than a tiny travel mouse that simply disappears into your bag.
The integrated thumb rest is particularly useful. It gives your thumb a natural place to sit, while the carved-out section on the other side makes room for your little finger. This makes the MD105 easier to grip and more comfortable to use over longer sessions. It is clearly better suited to people who prefer a traditional ergonomic mouse for everyday productivity, rather than those looking for an extremely compact design.
ASUS offers the MD105 in Milky White and Volt Green, both of which stand out in a category full of plain black mice. Its curved body and clean lines also make it feel more like a contemporary office accessory than a gaming peripheral.
Of course, ergonomics are personal. Its 72mm width and relatively tall 43mm profile may not be ideal for people with smaller hands, while left-handed users should look elsewhere altogether. It also takes up more space in a laptop bag than a compact travel mouse.
Still, for its intended audience, the MD105’s design makes a lot of sense. It is the sort of mouse you can comfortably keep beside a laptop or desktop throughout a full working day.
Asus Wireless Mouse MD105: Dual Wireless Connectivity
One of the ASUS MD105’s most useful features is its connectivity flexibility. It supports both Bluetooth and 2.4GHz wireless, giving you two simple ways to pair it with your devices.
The 2.4GHz connection uses the bundled USB receiver, while Bluetooth is particularly convenient for laptops, tablets and other compatible devices where you do not want to sacrifice a USB port. That came in handy with my MacBook, where I could pair the mouse directly over Bluetooth and keep the port free. ASUS claims a wireless range of up to 10 metres, which should be more than enough for a regular desk setup.
The MD105 can connect to up to three devices, making it practical for anyone who moves between a work laptop, personal desktop and perhaps a tablet. You do not need a separate mouse for every machine, and that becomes genuinely useful if you regularly switch between devices through the day.
The included USB receiver is also compact, measuring approximately 18.8 × 14.2 × 6.25mm, so it should not be especially cumbersome when left plugged into a desktop or laptop.
Compared with basic wireless mice that only work with a dedicated receiver, the MD105’s dual-mode setup gives it a meaningful edge.
ASUS Wireless Mouse MD105: Quiet Clicks, Useful Extra Controls
Another particularly appealing feature of the MD105 is its quiet operation. ASUS specifically highlights its near-silent clicks, and it is one of those things that becomes far more valuable once you start using a quieter mouse regularly.
Loud clicks can be surprisingly distracting during a long workday, especially in an office, library, classroom or even a bedroom late at night. The MD105 keeps that noise to a minimum, making it a sensible option if you work around colleagues, family members or anyone who would rather not hear every click.
You also get two additional side buttons. They do not turn the MD105 into an overly complicated multi-button mouse, but add a little extra convenience. Depending on your operating system and the app you are using, they can be useful for browser back and forward navigation or other assigned shortcuts.
ASUS Wireless Mouse MD105: Battery and Everyday Practicality
The MD105 runs on a regular AA battery, and ASUS includes one in the box. That may feel old-school next to the rechargeable mice that dominate this category, but there is a practical upside to it.
When the battery runs out, you can simply replace it and get back to work. There is no need to wait for the mouse to charge, keep a cable on your desk or remember to plug it in overnight. For someone who wants a no-fuss mouse, that convenience is hard to argue with.
Of course, people who prefer rechargeable peripherals may find this less appealing. ASUS does not quote a fixed battery-life figure either, noting that endurance will vary depending on usage habits and computing conditions.
So, it is best not to make assumptions about exactly how long a single AA battery will last. Your usage pattern, the wireless mode you use and other conditions will all affect battery life.
ASUS Wireless Mouse MD105: Compatibility
ASUS lists support for Windows 11, macOS 12 and ChromeOS, covering the major platforms most people are likely to use at home or work.
Bluetooth makes it particularly convenient for modern laptops, especially those with limited USB ports. If you prefer the familiarity of a plug-and-play setup, the bundled 2.4GHz receiver is there as well.
The MD105 also keeps things simple. You do not need to install a large companion app just to use its core functions, which is exactly what many people want from an everyday wireless mouse.
ASUS Wireless Mouse MD105: Who Should Buy It?
The ASUS MD105 is best suited to people who value comfort and everyday practicality over a long feature list or gaming-focused specifications.
It is a good fit for office professionals and students who spend hours working at a computer, as well as laptop users who want the flexibility of both Bluetooth and 2.4GHz wireless connectivity. Its near-silent clicks also make it a sensible choice for shared offices, libraries, classrooms and quiet rooms at home.
It is equally useful for anyone who regularly moves between multiple computers and wants one mouse that can handle those setups.
Gamers chasing competitive performance should look at a dedicated gaming mouse instead. Left-handed users, as well as those who need an extremely compact mouse for travel, may also find the MD105 less suitable.
ASUS Wireless Mouse MD105: Verdict
The ASUS Wireless Mouse MD105 understands exactly what it is meant to be. It is not trying to compete with gaming mice or premium productivity models loaded with programmable controls. Instead, it focuses on the things that matter in everyday use: comfort, reliable wireless connectivity, quiet clicks and straightforward controls.
Its ergonomic body and thumb rest make it a good fit for long hours at a desk. Bluetooth and 2.4GHz connectivity add useful flexibility for multi-device setups, while the three DPI settings are more than adequate for regular work and browsing. The PTFE feet also help it glide smoothly across a desk mat or mouse pad.
The AA battery setup and lack of gaming-focused features are reasonable trade-offs at this price. Its larger, right-handed shape will not suit everyone, though, particularly left-handed users or those who want a tiny travel mouse.
At ASUS India’s promotional price of ₹1,799, the MD105 is a sensible, accessible ergonomic wireless mouse. Just check the latest price before buying.
