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Karl Deisseroth, Peter Hegemann and Georg Nagel have won the 2026 Nobel Prize in Medicine for their pioneering work on optogenetics and the discovery of a molecular switch for nerve cells.

US-German trio wins medicine Nobel for work on optogenetics

Karl Deisseroth, Peter Hegemann and Georg Nagel have won the 2026 Nobel Prize in Medicine for their pioneering work on optogenetics and the discovery of a molecular switch for nerve cells.

The Nobel medicine prize was awarded Monday to US psychiatrist and neurologist Karl Deisseroth and German scientists Peter Hegemann and Georg Nagel for their pioneering work in the field of optogenetics.
Optogenetics involves controlling nerve signals with light, and helps researchers understand how specific cell types contribute to behaviours like learning, fear, addiction and movement.
The trio were honoured "for their discovery of a molecular switch for nerve cells", the Nobel Assembly said.
Using light, researchers are now able to switch individual neural circuits on or off in a brain.
They have been able to reveal neural circuits governing specific memories, feelings, and behaviours relevant for neurological and psychiatric disorders.
In clinical medicine, the method is being used in attempts to restore sight in people with visual impairment, and may one day lead to treatments for disorders such as Parkinson's disease and epilepsy.
"Optogenetics provides opportunities for mapping the brain in a way that we could once only dream of," Per Svenningsson, chair of the Nobel committee, said in a statement.
"Optogenetics has fundamentally altered our understanding of the brain. Every day brings new discoveries, helping to solve one of humanity's great mysteries: how our incredible brain works," the Nobel Assembly said.
The secretary general of the assembly, Thomas Perlmann, told reporters he was able to reach the three laureates by phone to break the news.
"That was great to talk to them. I first called Deisseroth, he was very tired when he answered. He was definitely asleep, but he woke up," he said.
- Illumination - In the early 2000s, Hegemann and Nagel were examining why a single-celled alga was able to swim toward a light source.
They discovered an algal protein with unique properties, called channelrhodopsin, found on the surface of the cell.
When illuminated by blue light, a channel opens through the protein.
Charged ions then flow into the cell, creating an electrical impulse. They found that any cell they put the protein in became light sensitive.
Deisseroth then introduced the gene for channelrhodopsin into nerve cells from rats.
By illuminating the cells with blue light, he was able to trigger a nerve signal.
He published his breakthrough in 2005, and two years later, made the light-controlled switch for nerve cells work in the brains of living mice.
In 2021, Deisseroth and Hegemann won the Lasker Prize for their work in the field, often considered a precursor to the Nobel.
Deisseroth, 54, is &nbsp;a professor at Stanford University in the US, while Hegemann, 71, is a neuroscience professor at Humboldt University of Berlin.
Nagel, 73, is a biophysics professor at the University of Wurzburg.
The Nobel prize for physics will be announced on Tuesday, followed by the chemistry prize on Wednesday and the literature prize on Thursday.
Some pundits have suggested that for literature, the Swedish Academy could follow up last year's award to Hungary's Laszlo Krasznahorkai with a woman writer, possibly from Central or Latin America.
Argentine author Samanta Schweblin, 48, could be one such pick, literary critic Lina Kalmteg told AFP.
- All eyes on peace - Perhaps the most keenly anticipated award is that due on Friday, the peace prize -- the only Nobel to be awarded in Oslo.
This year, some experts have suggested the jury could choose a laureate who enjoys broad consensus, after last year's winner, Venezuelan opposition leader Maria Corina Machado, stirred controversy.
Among possible laureates this year are a joint prize to Save the Children and Mykola Kuleba, a Ukrainian children's rights activist campaigning for the return of Ukrainian children illegally taken to Russia from occupied territories.
Others include Sudan's Emergency Response Rooms (ERR), a vast network of volunteers risking their lives to help people facing the double threat of war and hunger, and the Committee to Protect Journalists (CPJ) after the deadliest year on record for the profession in 2025.
The economics prize wraps up the Nobel season on October 12.
This year's laureates will receive their prizes -- a diploma, a gold medal and a $1.2-million cheque -- on December 10, the anniversary of the death in 1896 of the prize's creator, scientist Alfred Nobel.

A flydubai flight from Dubai to Tel Aviv made an emergency landing in Saudi Arabia after a reported cockpit attack. A passenger alleged that one pilot tried to crash the plane, while Israeli officials described the incident as possible terror attack.

Passenger on rerouted Flydubai flight says pilot tried to crash plane

A flydubai flight from Dubai to Tel Aviv made an emergency landing in Saudi Arabia after a reported cockpit attack. A passenger alleged that one pilot tried to crash the plane, while Israeli officials described the incident as possible terror attack.

A passenger on a rerouted flydubai flight that was bound for Tel Aviv said one of the pilots tried to crash the plane and kill everyone on board, after both pilots were found to be wounded on landing in Saudi Arabia.
In the first comment by an official, Israel's far-right national security minister Itamar Ben Gvir alleged an attempted "terrorist" attack in the incident, in which none of the passengers reported injuries.
The flydubai plane was forced to make an emergency landing in Saudi Arabia's Tabuk "at 9:45 am (0645 GMT) and its captain and copilot were found to have injuries and were transported to hospital", a statement from the company operating the airport said.
The low-cost carrier had earlier said flight FZ 1073 "experienced an incident while en route. The aircraft has landed safely in Tabuk Airport (TUU) and all passengers are safe and accounted for".
According to data from the Flightradar website, the aircraft suddenly lost altitude during the flight, dropping from nearly 34,000 feet at 0521 GMT to less than 17,000 feet at 0522 GMT.
Passenger Miryam Shira Ohayon said the plane was "pretty much out of control" when one of the pilots tried to stab the other while they were flying over Jordan en route from Dubai to Tel Aviv.
"So the co-pilot tried to murder the pilot and basically carry out a suicide attack on the plane," she told reporters by speakerphone held up by her mother who was waiting at Ben Gurion Airport near Tel Aviv.
"It was really on the way to crashing, and it was simply the resourcefulness of many people who took control of the co-pilot and neutralised him," she said.
"There was also a doctor who gave first aid, and people who treated both of them. Other than the pilot, there were no injuries, but the bigger fear was really a crash, which is exactly what he was trying to do."
Several Israeli media reported that a fight had broken out between the plane's pilots, reportedly causing a distress signal to be activated.
Israeli media also reported that two other pilots were flying on the plane as passengers, and that they had taken over the controls to carry out the emergency landing in Saudi Arabia.
At Ben Gurion airport, families gathered to await the return of their loved ones.
Earlier, Yasmin Abukasis, Ohayon's mother, told AFP her daughter called her from Saudi Arabia: "She said one pilot tried to kill the other pilot with a knife. They heard shouting".
Another passenger went to the cockpit "and saw a lot of blood. She started screaming 'come help' and some people went in and caught the guy", she added.
- 'Going down very fast' - "All the while, the plane started going down very fast. People thought they were going to die."
She added that two other pilots in the back later took over the controls.
Neither the airline nor authorities of the countries involved provided details on what happened on board or on the pilots' nationalities, but some Israeli media said one was Omani and the other Emirati.
Israel's Kan public broadcaster and Channel 12 reported that the Israeli military had scrambled fighter jets after fears of a possible hijacking.
The office of Israeli Prime Minister Benjamin Netanyahu said the premier had held consultations on the matter and was "monitoring developments".
Contacted by AFP, the Israeli military said it was "checking" the reports.
Meir Zohar, the father of passenger Ido Zohar, told AFP his son had told him by text message that he was well, but that he had no other news.
"We heard on the news what happened in the sky of Abu Dhabi," he said.
"He told us that everything is okay, he didn't tell me that much."
- Bloodied T-shirt - Israeli media, citing anonymous sources, reported that the passengers on board had stepped in to separate the two pilots during their altercation, publishing photos of a passenger with a bloodied T-shirt.
Channel 12 reported that authorities were investigating whether or not one of the pilots had attempted a possible suicide by trying to crash the plane, with the other pilot apparently intervening to prevent the crash.
An AFP correspondent in Tabuk, where the plane landed, saw heavy security near the airport, with several police vehicles and an ambulance parked at the terminal.
Access to the terminal remained open.
In photos sent to AFP by one of the passengers, travellers, including children, are seen gathered in an airport lounge, with some sitting on the floor, while one man is wearing a white T-shirt and jeans stained with blood.
The incident comes as tensions are high across the Middle East, amid the regional war that erupted in late February with US-Israeli strikes on Iran.
It also comes just ahead of close-fought Israeli elections due to be held at the end of October.
On Tuesday, Netanyahu said there were "indications" that Israel's enemies could try to attack ahead of elections, and was accused of "fear-mongering" by the opposition chief.

Two pilots were reportedly injured after an altercation on a flydubai flight from Dubai to Tel Aviv, forcing the aircraft to make an emergency landing in Saudi Arabia.

Flydubai Dubai-Tel Aviv Flight Diverted After Pilots Injured In Mid-Air Fight

Two pilots were reportedly injured after an altercation on a flydubai flight from Dubai to Tel Aviv, forcing the aircraft to make an emergency landing in Saudi Arabia.

Two pilots were wounded after they reportedly fought on board the plane they were flying from Dubai to Tel Aviv, and which was forced to make an emergency landing in Saudi Arabia on Wednesday.
The flydubai plane landed in Tabuk "at 9:45 am (0645 GMT) and its captain and copilot were found to have injuries and were transported to hospital", a statement from the company operating the airport said.
The low-cost carrier had earlier said flight FZ 1073 "experienced an incident while en route. The aircraft has landed safely in Tabuk Airport (TUU) and all passengers are safe and accounted for".
Several Israeli media reported that a fight had broken out between the plane's pilots, reportedly causing a distress signal to be activated.
Israeli media also reported that two other pilots were flying on the plane as passengers, and that they had taken over the controls to carry out the emergency landing in Saudi Arabia.
At Ben Gurion airport, families gathered to await the return of their loved ones.
Yasmin Abukasis, mother of passenger Miryam Shira Ohayon, told AFP her daughter called her from Saudi Arabia: "She said one pilot tried to kill the other pilot with a knife. They heard shouting".
Another passenger went to the cockpit "and saw a lot of blood. She started screaming 'come help' and some people went in and caught the guy", she added.
 - 'Going down very fast' -
"All the while, the plane started going down very fast. People thought they were going to die."
She added that two other pilots in the back later took over the controls.
Neither the airline nor authorities of the countries involved provided details on what happened on board or on the pilots' nationalities, but some Israeli media said one was Omani and the other Emirati.
Israel's Kan public broadcaster and Channel 12 reported that the Israeli military had scrambled fighter jets after fears of a possible hijacking -- with the hypothesis later dismissed.
The office of Israeli Prime Minister Benjamin Netanyahu said the premier had held consultations on the matter and was "monitoring developments".
"The incident is under control, and all measures are currently being deployed in order to return the Israeli passengers safely to Israel," a statement said.
Contacted by AFP, the Israeli military said it was "checking" the reports.
Meir Zohar, the father of passenger Ido Zohar, told AFP his son had told him by text message that he was well, but that he had no other news.
"We heard on the news what happened in the sky of Abu Dhabi," he said.
"He told us that everything is okay, he didn't tell me that much."
 - Bloodied T-shirt -
Israeli media, citing anonymous sources, reported that the passengers on board had stepped in to separate the two pilots during their altercation, publishing photos of a passenger with a bloodied T-shirt.
Channel 12 reported that authorities were investigating whether or not one of the pilots had attempted a possible suicide by trying to crash the plane, with the other pilot apparently intervening to prevent the crash.
According to data from the Flightradar website, the aircraft suddenly lost altitude during the flight, dropping from nearly 34,000 feet at 0521 GMT to less than 17,000 feet at 0522 GMT.
An AFP correspondent in Tabuk, where the plane landed, saw heavy security near the airport, with several police vehicles and an ambulance parked at the terminal.
Access to the terminal remained open.
The incident comes as tensions are high across the Middle East, amid the regional war that erupted in late February with US-Israeli strikes on Iran.
It also comes just ahead of close-fought Israeli elections due to be held at the end of October.
On Tuesday, Netanyahu said there were "indications" that Israel's enemies could try to attack ahead of elections, and was accused of "fear-mongering" by the opposition chief.

US Ambassador to China David Perdue said President Donald Trump once asked Chinese President Xi Jinping whether China wanted to buy American weapons amid concerns over US arms sales to Taiwan.

Trump offered to sell arms to Xi: US ambassador to Fox News

US Ambassador to China David Perdue said President Donald Trump once asked Chinese President Xi Jinping whether China wanted to buy American weapons amid concerns over US arms sales to Taiwan.

US President Donald Trump offered to sell arms to his Chinese counterpart Xi Jinping in response to concern over weapons sales to Taiwan, the US ambassador to China said in a Fox News interview that aired Sunday.
US arms sales to the self-ruled island, which China claims is part of its territory and has threatened to seize by force, have long been a thorny issue between Washington and Beijing.
The United States is required by law to supply Taiwan, which has a democratically elected president and legislature, with weapons for its defense.
US Ambassador to China David Perdue said the issue was raised again when Xi visited the United States last week.
"President Trump continues to say, 'Hey, we sell arms to other people around the world.' He actually asked President Xi -- would he like to buy some? -- at one point," Perdue said in the interview.
"There are continuing conversations about other sales, (Trump) and President Xi talk about that every time they get together," Perdue said, adding that the US position has not changed.
The White House did not immediately respond to AFP's request for comment.
White House officials said that the US had no plans to sell arms to China, according to the New York Times and the Wall Street Journal.
The US State Department said in a statement to the New York Times that "US law prohibits arms sales to China and there is no offer or plan to sell arms to China."
The Chinese foreign ministry did not directly answer when asked about the comments on Monday, but said China has "always strengthened its national defense capabilities based on its own needs, and remains committed to maintaining world peace and stability."
Beijing warned Taiwan in June that seeking independence "by relying on the United States or through military means is a dead end."
Washington approved a $11.1 billion arms sale to Taiwan in December, which Perdue said was a sale of "more arms to Taiwan than any other president since 1979."
The US paused a $14 billion weapons purchase by Taiwan in May, with Trump calling it a "very good negotiating chip" in dealings with China, raising fears that Taiwan's security could be traded away.
During his Washington trip, Xi repeated his warning that Trump should show "prudence" over Taiwan, and went further to urge the United States to oppose Taiwan independence explicitly.
Both leaders confirmed they would meet again at the APEC summit in Shenzhen, China, in November and the G20 forum at Trump's Doral resort in Miami in December.

CNN, MS NOW and Politico returned to the White House after a judge ruled their press access ban likely violated constitutional due process rights.

CNN, MS NOW, Politico allowed back in White House after judge's order

CNN, MS NOW and Politico returned to the White House after a judge ruled their press access ban likely violated constitutional due process rights.

CNN, MS NOW and Politico were allowed back into the White House on Thursday, six days after being banned by President Donald Trump, following a federal judge's order that the journalists have their access restored.
District Judge Timothy Kelly ruled overnight that revoking the White House press credentials of the three media outlets "likely violated their constitutional due process rights."
Reporters for CNN, MS NOW and Politico who attempted to return to the White House early Thursday ahead of a visit by Chinese President Xi Jinping were initially turned away by the Secret Service but were allowed in later around midday.
Journalists from other outlets surrounded CNN's tent on the White House driveway and filmed reporter Betsy Klein as she reported live following her return. "Welcome back," several journalists said.
In his ruling, Kelly took issue with how the White House went about expelling the three news organizations.
"The 'general rule' is that 'individuals must receive notice and an opportunity to be heard before the Government deprives them' of a constitutionally protected interest," the judge said.
Despite regaining access to the complex earlier in the day, CNN reported later Thursday that the White House had "denied two CNN journalists from covering Chinese leader Xi Jinping's arrival back at the White House for a state dinner."
The cable network reported that MS NOW journalists were also denied access to the arrival.
Trump has long attacked media that have aired critical coverage of him, repeatedly blasting the press as the "enemy of the people."
The Republican president barred CNN, MS NOW and Politico from the White House on Friday for distributing what he called "fake news" and "fiction and lies."
They filed a joint lawsuit asking for a temporary restraining order against the ban on the grounds that it violates the First Amendment of the US Constitution, which upholds the right to a free press.
Ahead of the ruling, the Department of Justice had argued that Trump can "control reporters' access to restricted presidential areas, such as the Oval Office."
"Access to the White House is a privilege -- not a right," it said.
 - National security? -
The White House Press Office accused CNN in a letter to the cable news outlet of "trafficking in verifiable falsehoods about national security and other issues, and publishing sensitive or classified information," with similar accusations leveled against MS NOW and Politico.
The letter to CNN cited several stories about the US-Iran war and a story on Trump's plans to build a military bunker below the planned East Wing ballroom which allegedly "disclosed 'top-secret' construction details."
Kelly, who was appointed by Trump during his first term, appeared unconvinced.
"The Court is skeptical -- at least on this record -- that Defendants' interest in safeguarding national security is the actual motivation for, or is even advanced by, the revocation of Plaintiffs' hard passes," the judge said.
In a rare move, the top five US broadcasters said that they were halting pool coverage of the White House -- where a broadcaster films on behalf of all television outlets for the day -- in solidarity with CNN.
"The public has a vital interest in receiving accurate, independent information about its government. No administration should restrict a news organization because it objects to its reporting," ABC, CBS, CNN, Fox and NBC said.

Donald Trump hosted Xi Jinping at a White House state dinner attended by top tech leaders, as trade, AI, Taiwan and Iran remained key issues.

Trump hosts Xi Jinping for state dinner as pomp masks tensions

Donald Trump hosted Xi Jinping at a White House state dinner attended by top tech leaders, as trade, AI, Taiwan and Iran remained key issues.

US President Donald Trump hosted Chinese leader Xi Jinping for a lavish state dinner at the White House on Thursday, after a day of pomp and ceremony that masked deep tensions between the rival superpowers.
Numerous US tech titans attended the banquet, including Tesla's Elon Musk, Apple's Tim Cook, Nvidia's Jensen Huang and Sam Altman of OpenAI, underscoring that trade and artificial intelligence were high on the agenda for Xi's visit.
Protesters gathered outside the White House as Trump and his wife Melania welcomed Xi and his wife Peng Liyuan for dinner, chanting slogans including "Xi Jinping is not welcome" and "Free Hong Kong," AFP reporters witnessed.
Earlier in the day, Trump proclaimed that he and Xi had made "tremendous strides" as he laid on pageantry including a military parade, a flyover and a tour of his new White House helipad.
"President Xi and I both understand that we represent different systems, but the ties between our people endure," Trump said at the dinner.
But Xi took a more restrained tone, calling for China and the United States to "coexist in peace" even as he laid down Beijing's red lines on AI, Taiwan and the Iran war.
He continued the theme in his dinner remarks, saying: "China and the United States must act as responsible major countries."
 - Bald eagle statue -
Trump presented Xi with a gift of a custom-made statue of a bald eagle -- the national symbol of the United States. Guests dined on yellow squash veloute, sesame crusted sea bass, and vanilla cremeux with White House honey ice cream.
The 80-year-old US president invited guests to tour the building site of his new $400 million ballroom after the dinner, saying: "In honor of you, you'll be the first people to step foot on that."
While business was on the menu at the state dinner, expectations of any major breakthroughs from Xi's visit are low.
One minor success -- the extension of a trade truce by two months until January -- was less than the two years that the Chinese had been hoping for.
Instead, the visit was more about spectacle than substance, with the pomp helping to smooth over the tensions that divide the world's two top economies.
A formal welcome on the White House South Lawn launched Thursday's events, before Trump and Xi inspected a military parade on the newly paved-over Rose Garden.
American military jets -- including a B-2 bomber of the type that bombed Iranian nuclear facilities last year -- then staged a flyover as US and Chinese flags flew over the West Wing.
As they began talks in the Oval Office, Trump joked that the Chinese had the friendliest press corps.
His comment came days after he barred outlets CNN, MS NOW and Politico from the White House -- although they returned on Thursday after a court order.
 - 'Great meeting' -
Trump later walked Xi out to see the new helipad he has built at the White House, and took the Chinese leader aboard his Marine One helicopter.
"We had a great meeting," Trump said, as the pair ignored questions on subjects including Iran, Taiwan, fentanyl trafficking and jailed Hong Kong pro-democracy media mogul Jimmy Lai.
But Xi's comments were often pointed.
In his arrival remarks he said the two countries must ensure there is "no conflict and no confrontation" and said that AI must remain "always under human control."
Trump has in contrast played down warnings that AI could threaten humanity.
Later in the Oval, Xi urged Trump to show "prudence" and oppose independence for the flashpoint of Taiwan, the self-governing island that Beijing claims.
The Chinese leader -- whose country has reportedly shared intelligence with Tehran -- also urged Trump to end the Iran war "through negotiation as soon as possible."
Xi's visit wraps up on Friday as the presidential couples pay a visit to the US National Archives, home to the Declaration of Independence, which marks its 250th anniversary this year.

Israeli PM Benjamin Netanyahu faced jeers and a walkout at the UNGA as he attacked allies and adversaries amid a tense reelection campaign.

Israel's Netanyahu denounces enemies, allies in fiery UN speech

Israeli PM Benjamin Netanyahu faced jeers and a walkout at the UNGA as he attacked allies and adversaries amid a tense reelection campaign.

Israel's Prime Minister Benjamin Netanyahu, facing a difficult reelection campaign at home, delivered a fiery UN speech Thursday assailing enemies and allies alike -- and sparking uproar in the chamber.
Locked in a tight race to stay in power in October 27 elections, Netanyahu used the global platform at the UN General Assembly to attack everyone from the leaders of Iran to New York's first Muslim mayor and partners Britain, France and Turkey.
Dozens of envoys from across the world walked out, some jeering and booing, while Netanyahu's own team stood and applauded, and the speaker of the session shouted for order.
"If there are any other moral cowards who haven't left this hall, please do so now," Netanyahu told those turning their backs on him.
He lashed out at New York's popular, leftist Mayor Zohran Mamdani as "antisemitic" and claimed that "since you were elected mayor of this city, many Jews no longer feel safe."
Mamdani had threatened to execute an ICC arrest warrant against Netanyahu, before conceding he did not have the authority.
The Hague-based International Criminal Court (ICC) said in 2024 it had reasonable grounds to believe Netanyahu was responsible for war crimes in the Gaza campaign, which responded to Hamas's deadly October 7, 2023 attacks. Netanyahu denies the ICC claims.
"Netanyahu used his speech to repeat baseless lies meant to sanitize his genocide of Palestinians," Mamdani said in response.
"Yet no lie can change the fact that he remains the subject of an International Criminal Court arrest warrant alleging war crimes and crimes against humanity."
Adding to tensions, dozens of protesters, some brandishing "stop the genocide" banners, gathered near the United Nations. Several demonstrators were detained, including Hollywood star actor Susan Sarandon.
One of Netanyahu's fiercest critics, Palestinian President Mahmoud Abbas, was unable to attend the UN gathering after the Trump administration refused him a visa.
In a video message played ahead of Netanyahu's speech, Abbas said, "We reject these unlawful punitive measures, and we reject the accusations and justifications on which they were based."
 - Netanyahu attacks Britain, France -
Britain and France, historic partners of Israel that have become increasingly outspoken in their criticism, were also in Netanyahu's firing line.
The two European nations have both imposed limited sanctions on Israeli exports from the occupied West Bank.
And French President Emmanuel Macron drew Israel's ire for claiming in his own UN speech that Hamas was not active in the West Bank. Hamas's stronghold has traditionally been Gaza.
Netanyahu attacked Britain and France for their past colonial empires during his turn at the lectern.
"They accuse Israel, tiny Israel, of colonialism -- some colonialism. And who's accusing us? Among them are people in Britain and in France. For God's sakes, they invented the term," he said.
Netanyahu already had poor relations with Macron, who led a push by Western nations at last year's UN General Assembly to recognize a Palestinian state.
 - Iran's 'murderous dictatorship' -
Netanyahu had especially harsh language on Iran, calling it a "murderous dictatorship."
He said the war in which Israeli and US forces have attacked Iran for close to seven months had stopped Tehran from being able to develop nuclear weapons.
"I vowed to prevent Iran's murderous dictatorship from developing atomic bombs, nuclear weapons aimed at destroying Israel, nuclear weapons that could threaten the entire world," he said.
He said the fall of Iran's leadership, whose UN envoy displayed a portrait of slain Quds Force commander Qasem Soleimani on their vacant desk, was not "far."
Despite the onslaught, Iran's government has retained control and continues to defy the United States by effectively blocking the Strait of Hormuz.
 - Pager bombs -
During his speech, Netanyahu brandished a pager device like those that Israeli intelligence reportedly engineered with explosives before having them shipped to operatives of Iran-backed Lebanese militant group Hezbollah.
They were later detonated, maiming hundreds of Hezbollah operatives but also civilian bystanders.
He accused Turkey of backing Iran-backed Islamist group Hamas, going on to call the country's leader Recep Tayyip Erdogan a "tyrant."
Burhanettin Duran, the Turkish presidency's communications director, dismissed the comments as "baseless accusations" that were "incompatible" with UN ideals, state-run news agency Anadolu reported.
Netanyahu is only making a whirlwind stop in New York before rushing back to Israel, where the election campaign is in full swing. He is not scheduled to meet any top US leaders.

A US federal judge has ordered the Trump administration to reinstate White House access for CNN, MS NOW and Politico after their reporters were barred over alleged false reporting.

US judge blocks White House ban on CNN, MS NOW, Politico

A US federal judge has ordered the Trump administration to reinstate White House access for CNN, MS NOW and Politico after their reporters were barred over alleged false reporting.

The Trump administration must immediately reinstate White House access for CNN, MS NOW and Politico, a US federal judge ordered Thursday, after their reporters were banned from the premises.
President Donald Trump has long attacked media outlets that have aired critical coverage of his campaigns and administrations, repeatedly blasting the press as the "enemy of the people."
The three outlets were barred from the White House by the billionaire former reality TV star on Friday as punishment for distributing what he branded "fake news" and "fiction and lies."
Theodore Boutrous, who is representing the media outlets, told AFP on Thursday that "this is a strong ruling vindicating freedom of the press, due process and the rule of law. We greatly appreciate the court's swift action."
CNN, MS NOW and Politico filed a joint lawsuit asking for a temporary restraining order against the ban on the grounds that it violates the First Amendment of the US Constitution, which upholds the right to a free press.
Judge Timothy Kelly found that the revocation of press passes "likely violated their constitutional due process rights," according to the eight-page ruling issued Thursday.
"The 'general rule' is that 'individuals must receive notice and an opportunity to be heard before the Government deprives them' of a constitutionally protected interest," Kelly wrote.
The judge said that press credentials held by employees of the three outlets will be reinstated "until further Order of the Court or the expiration of this Temporary Restraining Order", which is to remain in effect for 14 days.
Kelly added that the order cannot be immediately appealed.
AFP has contacted the Department of Justice for comment.
Ahead of the ruling, the Department of Justice had argued Trump can "control reporters' access to restricted presidential areas, such as the Oval Office."
"Access to the White House is a privilege -- not a right," it said.
&nbsp;
- 'National security' -
The White House Press Office accused CNN in a letter to the cable news outlet of "trafficking in verifiable falsehoods about national security and other issues, and publishing sensitive or classified information," with similar accusations leveled against MS NOW and Politico.
The letter to CNN cited several stories about the US-Iran war and a story on Trump's plans to build a military bunker below the planned East Wing ballroom which allegedly "disclosed 'top-secret' construction details."
Boutrous told the judge on Wednesday that in Trump's Truth Social post announcing the bans, the president "didn't say anything about national security."
The lawyer argued that being punished for reporting on national security issues "that the government would rather have not be reported on is just contrary to First Amendment principles."
Kelly said the stories identified in letters to the outlets were "routine".
"The Court is skeptical -- at least on this record -- that Defendants' interest in safeguarding national security is the actual motivation for, or is even advanced by, the revocation of Plaintiffs' hard passes," Kelly said, referring to the White House press credentials.
Journalists for the three news organizations were denied access to the White House grounds on Saturday and had their passes confiscated, in the latest flare-up of the 80-year-old Republican president's assault on mainstream US media.
&nbsp;
- 'Shouldn't be here' -
In a previous case involving CNN during Trump's first term, Kelly, a Trump appointee, ordered the White House to temporarily restore access for a CNN reporter whose pass had been revoked.
In a rare move, the top five US broadcasters said Monday that they were halting pool coverage of the White House -- where a broadcaster films on behalf of all television outlets for the day -- in solidarity with CNN.
"The public has a vital interest in receiving accurate, independent information about its government. No administration should restrict a news organization because it objects to its reporting," ABC, CBS, CNN, Fox and NBC said.
The White House Correspondents' Association and nearly 50 news organizations also filed a brief with the court calling for the bans on CNN, MS NOW and Politico to be reversed.
Trump appeared to suggest on Tuesday that CNN should not be covering him outside of the White House either.
"I'm surprised that CNN is here covering me. You shouldn't be here," Trump told a reporter at the UN General Assembly in New York.
The White House launched a streaming channel, Trump TV, on Monday which it said would show "top videos, major remarks, and must-see highlights streaming 24/7 and updated in real time."
The ban came at a time when Trump's approval ratings are at record lows, his Republican Party risks losing control of Congress in November's midterm elections, and the Middle East conflict drags on with no end in sight.

Ukraine accused the US of failing to warn it about Russian missile attacks and slowing Starlink services used by its military, as strikes killed five people in Kyiv and disrupted power supplies.

Ukraine accuses US of helping Russia as missiles hit Kyiv

Ukraine accused the US of failing to warn it about Russian missile attacks and slowing Starlink services used by its military, as strikes killed five people in Kyiv and disrupted power supplies.

Ukraine on Wednesday accused the United States of helping Russia, saying Washington failed to warn it of incoming missile strikes and slowed the Starlink system it relies on for its battlefield communications and frontline logistics.
US President Donald Trump on Tuesday insisted Washington was still helping Ukraine while a US official told AFP on Wednesday that its policy had "not changed". The EU also said there were "no indications" sharing had stopped.
Ballistic missiles have now struck the Ukrainian capital, Kyiv, for two nights running -- before air raid sirens could sound to warn people to take cover in basements, bomb shelters or metro stations.
Energy facilities were targeted, cutting power to more than 600,000, despite Trump's surprise announcement of an "energy ceasefire" in the nearly five-year conflict.
"Russia has never before shown such ostentatious disrespect toward the United States," said Ukraine's President Volodymyr Zelensky.
"Russia does not consider the American President's statements strong."
Zelensky said on Tuesday night that the lack of notice from Ukraine's Western partners about imminent Russian ballistic-missile launches was "completely unjust".
 - Jet-powered drones - The lack of warning has been reported only rarely over the course of the nearly five-year conflict and Ukrainian officials have suggested the Russian military's use of hard-to-detect missiles or potential technical issues could be to blame.
But one senior Ukrainian official pointed the finger at Washington after slower speeds were reported on Wednesday on some Starlink internet terminals used by its military.
"It's obvious they (the United States) are helping Russia for some reason," the official told AFP, following reports that Washington had threatened to pull intelligence-sharing that Kyiv relies on to detect incoming attacks.
Zelensky adviser Sergiy Beskrestnov linked the attacks and the Starlink restrictions, as the network was "the most effective solution" for protecting Ukraine against fast-moving Russian attack drones.
"Through their actions, our partners are depriving us of one of the few chances we have to defend the country against jet-powered Shahed drones," he wrote on Telegram.
Starlink's owner Elon Musk last weekend backed Trump, who has enraged Western allies by announcing a diesel-supply deal with heavily sanctioned Moscow, and blindsided both sides in the conflict by announcing an "energy ceasefire".
Trump also angrily hit out at Zelensky -- and even suggested he should be replaced as president -- over Ukrainian long-range attacks on Russian energy infrastructure, and urged him to stop.
 - Russia 'carefully noting' - Russia is watching for any sign Washington's backing for Ukraine may have shifted, the Kremlin said.
"We are carefully noting all this. It is too early to draw any systemic conclusions," Kremlin spokesman Dmitry Peskov told reporters.
Five people were killed and dozens more wounded in Kyiv on Wednesday, the authorities said, while significant damage to facilities and equipment knocked out power to swathes of the city.
Power plants also came under ballistic-missile attack in the eastern Kharkiv region, hitting electricity and heating infrastructure, Prime Minister Sergiy Koretsky said.
NATO chief Mark Rutte urged alliance members to step up support for Ukraine's air defences.
"With winter coming and with Russia's aggression unrelenting, allies need to do more, especially in support of air defence," Rutte said.
Zelensky, expected in London on Wednesday for talks with UK Prime Minister Andy Burnham, has said Ukraine is prepared to hold off from striking Russian energy infrastructure.
But he accused the Kremlin of having "squandered the opportunity for de-escalation".
Russia has previously targeted Ukraine's power stations and heating infrastructure, crippling supplies before winter, when temperatures can plummet to as low as -20C.
Ukraine has been pushing its allies for more military support as Kyiv increasingly comes under attack, particularly the supply of advanced interceptor systems to shoot down missiles and jet-powered drones.
Russian ballistic missile attacks were also reported in Zhytomyr in the northwest, and other strikes hit Sumy in the northeast and Chernigiv in the north.
Two people were killed in the central Dnipropetrovsk region and a further person in Zaporizhzhia in the southeast, the authorities said.
The governor of Russia's southwestern Saratov region, citing preliminary estimates, said a Ukrainian drone strike had killed one person in the city of Balakovo.
Moscow mayor Sergey Sobyanin said air defence forces had downed nearly 500 drones flying towards the Russian capital overnight.
Russian authorities said around 160 more were brought down over the Rostov region, while others targeted Moscow.

World

Thousands of protesters, including Greta Thunberg and presidential candidate Jean-Luc Mélenchon, marched across France demanding better school conditions, more teachers and improved facilities.

'We're not giving up': Activist Thunberg joins France student protests

Thousands of protesters, including Greta Thunberg and presidential candidate Jean-Luc M&eacute;lenchon, marched across France demanding better school conditions, more teachers and improved facilities.

Thousands of protesters marched through central Paris on Tuesday as part of nationwide demonstrations supporting high school pupils who have been protesting for better classroom conditions, with Swedish activist Greta Thunberg taking part.
With just six months to go before elections to replace President Emmanuel Macron, French authorities had been hoping that the protests were easing ahead of half-term holidays starting at the end of this week.
But teenagers at high schools called lycees -- backed by university students, teachers, unions and the far-left opposition party France Unbowed (LFI) -- have said their demands have not been met.
French presidential candidate Jean-Luc Melenchon was seen among the crowd of demonstrators in Paris.
Outside the Paris city hall, demonstrators -- mostly university students -- gathered in the early afternoon to the tune of an orchestra playing the The Rebel Fanfare from the Star Wars movies.
"I'm expecting a surge of solidarity," said 20-year-old Patricia, not wishing to give her surname.
"We're not giving up the fight, whether it's for the high school students who were hit with a harsh crackdown, or for denouncing police violence," she added, referencing &nbsp;multiple allegations of police brutality against protesters in recent weeks.
The education ministry said 214 schools were closed on Tuesday. Most of these were high schools out of the country's 3,700.
University student union l'Union Etudiante reported that 90 percent of universities had closed nationwide to show support.
Thunberg, who became famous as a teen for school strikes to demand action on climate change, stood among pupils demonstrating outside a school in the capital's largest suburb, Saint-Denis.
"Young people are not being included in the conversation. Our future is being robbed away from us," the 23-year-old told reporters outside the Paul Eluard high school.
 - 'Country without a future' - French students say they are determined to press their demands for solutions to too many absent teachers, dilapidated buildings, overcrowded class schedules and other grievances.
The protests, launched late last month, have seen teenagers pile up dumpsters and security barriers outside hundreds of lycees.
Rallies were also underway in other cities on Tuesday.
In the western city of Nantes, thousands marched behind a banner reading "Schools without money, a country without a future".
"I think there are a lot of us in France who are still motivated," 16-year-old Mariolino said.
"Those who think the anger will disappear with the holidays just don't get it."
In the northeastern city of Strasbourg, Adeline Ferier, 42, a middle school French teacher, said she was demonstrating to support her 16-year-old daughter.
"I think it's great that young people are aware of inequalities and are getting involved," she said.
More than 70,000 people took to the streets last Thursday in the last major event of the movement. 
- 'Issues that deserve time' - The demonstrations in recent weeks have mostly been peaceful, but clashes have occasionally broken out with police.
More than 6,800 people -- largely minors -- have been taken into police custody over the course of the protests, according to the justice ministry.
Police have opened internal investigations into 24 allegations of brutality against demonstrators.
Some 147 teaching staff members have been injured in the protests, the education ministry said.
Authorities said fireworks fired through tubes on Monday injured two school workers in Reims, one school worker in a Paris suburb and a police officer outside a school in Marseille.
Tuesday's demonstrations supporting the students were to be followed on Saturday by wider public rallies against the rising cost of living.
Macron, speaking to reporters at a car show on Monday, urged restraint from protesters.
"These are issues that deserve time, consultations, discussion and respect," Macron said just months before elections to replace him.
After last week's nationwide demonstrations, the government promised that some 3,000 substitute teachers would be deployed in the coming days to replace absent staff at the 114 worst-affected high schools.
The education minister said on Tuesday that 35 percent had already been assigned.
High school students are demanding a 10 billion-euro ($11 billion) boost for lycees.

Ukrainian President Volodymyr Zelensky warned that Kyiv would respond if Russia did not agree to an energy ceasefire announced by US President Donald Trump.

Zelensky vows to respond as Moscow silent on 'energy ceasefire'

Ukrainian President Volodymyr Zelensky warned that Kyiv would respond if Russia did not agree to an energy ceasefire announced by US President Donald Trump.

Ukraine's President Volodymyr Zelensky said Monday his country would respond if Russia did not agree to the "energy ceasefire" announced by US President Donald Trump.
The Kremlin refused to say if an energy target truce was in place. Ukraine said that Russia struck its power plants and gas facilities after Trump posted on social media that a deal had been reached.
"If Russia does not agree to an energy ceasefire, we will respond," Zelensky told the Warsaw Security Forum via videolink on Monday.
Trump sowed confusion when he said there was an agreement &nbsp;between Russia and Ukraine without providing details, sparking astonishment in Kyiv, silence from Moscow. Ukraine's Western allies have supported Zelensky.
Trump's administration has pushed to end Europe's deadliest conflict since World War II -- now in its fifth year -- but diplomacy has so far failed to end fighting.
With gas prices surging ahead of US midterm elections, Trump has turned to major oil producer Russia as a possible source of relief, unilaterally announcing the halt on strikes after easing sanctions on Moscow to enable diesel exports.
"We are waiting for the details of the conversation between the Americans and the Russians, and we are waiting to see what specific steps the Americans are ready to take," Zelensky said.
Zelensky added that any ceasefire must apply on the ground and not just on social media.
"An energy ceasefire and other steps to reduce escalation and guarantee security are truly needed here in reality, not just on Truth Social," Zelensky said.
The Kremlin on Monday refused to say if it had agreed to an energy ceasefire.
"Contacts are continuing. As soon as we have anything to say on this matter, we will be sure to let you know," Kremlin spokesman Dmitry Peskov told reporters, including AFP.
Moscow also rejected Kyiv's call for a separate 60-day complete ceasefire to enable it to hold elections, following Trump's surprise weekend remarks over the weekend urging Ukraine to stage a nationwide presidential vote.
"We don't want a ceasefire, we want long-term peace," Peskov said. "I do not think he deserves a respite," Foreign Minister Sergei Lavrov added.
Russia's President Vladimir Putin has repeatedly said Moscow intends to seize the rest of east Ukraine by force and has rejected face-to-face talks with Zelensky.
In recent weeks, Russia has increased strikes on Ukraine -- especially on its capital Kyiv -- as Ukrainians brace for another winter of war.
Trump's announcement came two days after he declared an easing of US sanctions on Russian diesel, infuriating Ukraine and its European allies.
- Europeans sceptical - European leaders had welcomed Trump's ceasefire call on Sunday, but many were cautious.
"Russia is not interested in a ceasefire, or in de-escalation or peace. It is interested only in domination," Poland's prime minister Donald Tusk told the Warsaw Security Forum.
He added that "this was the moment" when Europe and the United States should stand together on Russia, saying that "Ukraine is fighting for survival, while Russia is fighting for dominance."
Many in Europe were waiting for Washington to provide more details.
In Paris, President Emmanuel Macron said Monday appeared wary.
There can only be progress "if there is a real truce on both sides," Macron told reporters, saying "the facts show Russia has continued to bomb energy infrastructure in the last hours".
But he added: "We say 'yes' to seeking an energy ceasefire and resuming peace talks ... but 'no' to giving in to the Russian threat."
Britain's Prime Minister Andy Burnham said Sunday that he backed Trump's call for the ceasefire, but warned that Moscow had intensified strikes on Ukraine's energy infrastructure over the weekend.
"This is an attack on Ukrainian civilians, plunging them into cold and darkness," he said.
Kyiv's European allies have worried that Trump will be too soft on Russia and that Washington will strike a deal on Ukraine over their heads.
Russia's war against Ukraine, which the Kremlin launched in 2022, has killed hundreds of thousands.

Five people remain missing after flash floods swept away more than 200 houses and five bridges along Nepal’s Budhi Gandaki river in Gorkha district. Authorities rescued 95 people, including nine foreigners, on Sunday.

Nepal Flash Floods Sweep Away 200 Houses, Five Bridges; Five People Missing

Five people remain missing after flash floods swept away more than 200 houses and five bridges along Nepal&rsquo;s Budhi Gandaki river in Gorkha district. Authorities rescued 95 people, including nine foreigners, on Sunday.

Nepali rescuers searched for five missing people on Monday, a day after devastating flash floods swept away more than 200 houses and five bridges along the Budhi Gandaki river.
Videos showed a dark, debris-filled river surging through the hills in central Nepal's Gorkha district.
No deaths have been confirmed.
On Sunday, 95 people including nine foreigners were rescued.
"We are continuing our work on rescue and relief," Raja Ram Basnet, Nepal Army spokesman told AFP, adding that four helicopters had been deployed.
"We do not have any new information on the five missing," he added.
About 150 foreign trekkers are in the area, according to the Trekking Agencies' Association of Nepal, many on the popular Manaslu circuit trek.
"We are working with authorities to rescue those who are stranded because of the roads," the association's president Sagar Pandey said.
Authorities were also delivering aid to affected communities, with many residents fleeing their homes on Sunday morning as the torrent hit.
The flood also struck hydropower plants, according to the national disaster agency.
"I screamed out loud to get people out. Just a few minutes after people ran out the flood crashed through," local resident Indra Bahadur Gurung said.
"We have always lived here, and find it difficult to leave. I hope the government will manage something safe for us soon."
 - 'Reducing future risks' - Preliminary data suggests that a landslide had dammed the river. It then burst, with the water surging downstream.
"The government has already begun taking the necessary steps to restore normal life," Prime Minister Balendra Shah said in a post on social media late Sunday.
He urged residents to stay in safe locations and to avoid travel on risky roads and bridges.
Nepal is still recovering from devastating floods on August 26, triggered by a mountain glacial collapse, which killed more than 1,400 people and left over 5,000 missing.
Shah told the United Nations last month that the August flooding "was a warning to the world" about the rising dangers of climate change.
Basanta Raj Adhikari, director at the Centre for Disaster Studies at Tribhuvan University, said that the latest flood showed the need for better monitoring.
"The frequency of the disasters is dangerous... it shows we need to go beyond our traditional river-level based early warning systems," Adhikari said, suggesting satellite images and seismometers could help detect events earlier.
The Kathmandu-based International Centre for Integrated Mountain Development said Sunday that the floods highlighted the "range of hazards capable of generating destructive floods" in Himalayan river systems.
"Understanding what triggered this flood will be critical for reducing future risks and strengthening resilience," the centre's director general Pema Gyamtsho said in the statement.
Heavy rainfall in late September also triggered floods and landslides, killing at least 21 people, according to the disaster agency.

Israel marked the third anniversary of Hamas's October 7 attack with tributes at massacre sites, fresh strikes on Gaza and political debate ahead of October 27 elections.

Mourning, war and elections as Israel marks October 7

Israel marked the third anniversary of Hamas's October 7 attack with tributes at massacre sites, fresh strikes on Gaza and political debate ahead of October 27 elections.

Israel marked the third anniversary of Hamas's October 7 attack on Wednesday with silent tributes, new strikes on Gaza and intense political debate, weeks before elections in which the country's deadliest day will be front and centre.
At the site of the Nova music festival, where Hamas militants in trucks and paragliders opened fire around dawn on October 7, 2023, family members bowed their heads in silence -- although at least one instead put on techno music in tribute to the fallen.
Both at Nova and the Kfar Aza kibbutz, another site of mass killings three years earlier, AFP reporters heard loud bangs from across the border in Gaza during the commemorations as Israel carried out new strikes, despite a ceasefire officially in place for the past year.
Gaza officials said at least two people were killed in overnight strikes in the territory, most of which has been reduced to rubble in relentless bombing in retaliation for the worst attack ever against Israel.
At the Nova site, Katia Zohar, whose daughter Bar Zohar was killed at age 23, called the start of the attack at 6:29 am (0329 GMT) "the minute that changed our lives forever".
"Sadly I remember everything," Zohar said. "The moment she called for me to come and pick her up because there were missiles in the air. Then the second time when she called from the road, screaming that they were shooting at her."
Anna Davitashvili, 53, paid tribute to her eldest son Shaun, who was killed at 25 at Nova alongside friends, by playing the last track of techno music that the partygoers were dancing to when the attack began.
"I feel him here. I'm terribly sorry that I couldn't save him, I couldn't help him get out of this massacre," she said, tears filling her eyes.
 - Election battle -
On October 27, Israel will hold elections for the first time since the attack, with polls showing a tight race for Prime Minister Benjamin Netanyahu, who in three years has ordered the massive offensive in Gaza and fought wars against Hezbollah in Lebanon as well as Iran, whose cleric-run government backs Hamas.
At the Nova site, Naftali Bennett, a former prime minister seeking to oust Netanyahu, told reporters of the attack: "This was a colossal failure of the state of Israel, which was established to defend Jews in our land."
The centre-left Democrats Party put online footage of the attack, without commentary.
"A government that for three years has not destroyed Hamas's rule is a government dangerous to Israel," Democrats leader Yair Golan said.
Netanyahu marked October 7 with official ceremonies in Jerusalem on Monday, which was closer to the anniversary on the Jewish calendar.
He said there would be "no forgiveness for the murderers" and vowed never to allow rule in Gaza by Hamas, which has faced major losses but remains in control of part of the territory.
Hamas, while battered, remained defiant on the third anniversary, issuing a statement calling October 7 "a glorious day of our people's history".
The group said it had "smashed the myth of the invincible army", calling the attack "a natural response to, and culmination of, decades of bitter suffering" including Israel's blockade of Gaza imposed since the Islamist movement seized the territory in 2007.
 - Shock to Israeli psyche -
October 7 delivered a deep shock to the psyche of Israel, which has prided itself on protecting its borders despite long odds.
Israelis had a more triumphant narrative last week when passengers helped foil an attack by the co-pilot of a flydubai flight to Tel Aviv, although questions were soon raised on why he was allowed to fly.
On October 7, Palestinian fighters breached the border, storming southern Israel with gunfire, rockets and grenades.
A total of 1,221 people died in the attack, according to an AFP tally based on official Israeli figures.
Militants also dragged 251 hostages into Gaza, 44 of them already dead.
Israel's military offensive has displaced nearly the entire population of Gaza and killed more than 74,200 people, according to Gaza's health ministry, which is under Hamas authority and whose figures are considered reliable by the United Nations.

At least 20 people were killed in Russian strikes across Ukraine on Wednesday, including 14 in Pryluky after a missile destroyed a five-storey apartment building. Authorities said 50 people were wounded, including seven children.

Heavy casualties in Ukraine after Russian strikes

At least 20 people were killed in Russian strikes across Ukraine on Wednesday, including 14 in Pryluky after a missile destroyed a five-storey apartment building. Authorities said 50 people were wounded, including seven children.

At least 20 people were killed in Russian strikes across Ukraine on Wednesday, the authorities said, including 14 when a missile destroyed an apartment block in the north of the country.
Emergency services picked through the rubble of the flattened five-storey building in Pryluky, in the Chernigiv region, in a frantic search for survivors.
But hopes faded as the toll jumped by early afternoon.
"The death toll... has risen to 14, including four children," the state emergency services said. "Fifty people were wounded, including seven children."
Fifteen people, including a child, were rescued, they wrote on Telegram.
Ukraine's President Volodymyr Zelensky had warned the public on Tuesday night that Russia was planning "massive" strikes, particularly against the country's energy infrastructure.
"The Russians wanted to strike painfully and demonstratively," he said on Wednesday, calling it "one of the most vile strikes" in the nearly five-year conflict.
Two people were killed when missiles slammed into high-rise buildings in Dnipro and Kremenchuk in central Ukraine, while two others lost their lives in Oleksandriya, he added.
In the capital, Kyiv, strikes killed two people.
Kyiv has come under increased attack in recent weeks as winter approaches, with air raid sirens wailing nearly constantly to warn of incoming Russian strikes.
Residents hunkered down in subway stations overnight, hauling duffel bags, sleeping mats and blankets, after air alerts sounded warning of attacks.
"We grabbed our things and came here, we live right next door," Iryna Rybalchenko, who works in a bank, told AFP, sitting on the platform wrapped in a dark hoodie and surrounded by bags.
"The whole of Kyiv is in a state of fear. We were stuck at work today and everyone &ndash;- our group chats, our bosses &ndash;- were messaging us to be careful."
Russia launched at least 50 missiles and 130 drones overnight against several regions including Dnipropetrovsk, Kyiv, Kharkiv, and Poltava, Ukraine's air force said.
Zelensky said that although some were shot down, ballistic missiles were "the greatest challenge", and new air defences were "a vital necessity" to help Ukraine defend itself.
- 'Tearing Kyiv apart' -
The two victims in Kyiv died in a fire in the densely populated Darnytskyi neighbourhood as a result of Wednesday's attack, the city's mayor Vitaly Klitschko said.
He had warned last week the capital should now be on a war footing as the enemy was "tearing Kyiv apart" with strikes on bridges and energy infrastructure.
The renewed attacks had triggered scheduled power cuts on Tuesday, which plunged parts of Kyiv into darkness to ease the pressure on the battered grid.
A familiar rumbling sound of the generators, used to get through power cuts, filled the streets again, bringing back memories of the previous winter, when systematic Russian attacks regularly cut power and heating.
In the evening, Zelensky warned residents to monitor for air raid sirens, saying in his nightly address that "there is updated intelligence information regarding the preparation by the Russians of a massive strike".
Military monitoring channels also said they expected a large-scale Russian attack, combining cruise and ballistic missiles with fast-moving jet-powered drones.
Zelensky said the military was "ready to respond, to the extent that our defence systems allow".
The air force said in the morning that it intercepted five ballistic missiles, as well as 39 cruise missiles and over &nbsp;100 drones.
Ukraine has been struggling to down the new and fast-moving jet-powered drones, as well as the ballistic missiles that are harder to intercept.
"The children were absolutely terrified. Whenever there's heavy shelling, we try to head underground," Daria Medvedeva, 36, told AFP.
Concern has mounted about rising civilian casualties on both sides, as Ukraine also steps up its long-range attacks on Russian targets that it says are vital to its war effort.
Zelensky said Ukraine's "just responses" to Russian strikes saw it hit two oil facilities and a training ground in the Perm, Samara and Astrakhan regions, as well as the Black Sea.

Israel has put its military on high alert ahead of the October 7 anniversary, with Defence Minister Israel Katz warning Hamas and Gaza's population of a "heavy price" if Israeli forces are attacked.

Israel puts military on alert for Oct 7 anniversary, warns Gazans

Israel has put its military on high alert ahead of the October 7 anniversary, with Defence Minister Israel Katz warning Hamas and Gaza's population of a "heavy price" if Israeli forces are attacked.

Israel's defence minister on Tuesday said he had put the military on high alert before the anniversary of Hamas's October 7, 2023 attack, warning Gazans would pay a "heavy price" if forces were harmed.
The office of Defence Minister Israel Katz said the instruction came "in light of intelligence regarding Hamas's intentions to attempt to carry out attacks and terror operations against our forces in Gaza on that day".
"If, heaven forbid, our forces are harmed, the ones who will pay the heavy price will be Hamas and the population of Gaza -- beyond all proportion," the statement added.
Israeli Prime Minister Benjamin Netanyahu Tuesday suggested during a government meeting that Hamas could try to attack Israel ahead of elections later this month.
"We are prepared for this; first and foremost, we will thwart such attempts, and in any case, we will respond with overwhelming force if they make this mistake," Netanyahu said.
Israelis will head to the polls on October 27, with Netanyahu locked in a tight race for re-election.
Hamas's October 7, 2023 attack was the deadliest in Israel's history, resulting in the deaths of 1,221 people, according to an AFP tally based on official Israeli figures.
Militants also dragged 251 hostages into Gaza, 44 of them already dead.
In response, Israel launched a military offensive that has left most of Gaza in ruins and killed more than 74,200 people, according to Gaza's health ministry, which is under Hamas authority and whose figures are considered reliable by the United Nations.
Since a ceasefire was declared last October, Israeli forces have killed more than 1,440 people in Gaza, according to the ministry.
On Monday, during a state ceremony to mark three years since the attack, Netanyahu said there would be "no Hamas rule in Gaza" and vowed to continue targeting anyone who was involved in the attack or who held hostages.

World

Ukraine accuses US of helping Russia as missiles hit Kyiv

'We're not giving up': Activist Thunberg joins France student protests

Zelensky vows to respond as Moscow silent on 'energy ceasefire'

Nepal Flash Floods Sweep Away 200 Houses, Five Bridges; Five People Missing

Israel marks 3rd October 7 anniversary with tributes, Gaza strikes and election battle

Heavy casualties in Ukraine after Russian strikes

Israel puts military on alert for Oct 7 anniversary, warns Gazans

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