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Medical trials of a novel drug combination show that the drugs can together shrink tumours in half of the patients with an advanced form of the disease.

‘Fantastic’ success of ovarian cancer treatment in trial offers a ray of hope

Drug combo shrinks tumours in half of ovarian cancer patients in trial
The drug pair blocks the signals that cancer cells need to grow
Experts hail the results as 'fantastic' news for cancer patients
Treatment could benefit where cancer is unresponsive to other therapies
Drug combination used in the trial:&nbsp;VS-6766 and&nbsp;defactinib
46% of 25 patients witnessed&nbsp;significant tumour shrinkage
64% of patients with KRAS-driven tumours saw improvement
Phase of trials for the drug treatment is&nbsp;already underway
If results repeat in larger trial, this could be a significant advancement

Medical trials of a&nbsp;novel&nbsp;drug combination show that the drugs can&nbsp;together&nbsp;shrink tumours in half of&nbsp;the&nbsp;patients with an advanced form of the disease.

A pathbreaking development in the world of cancer treatment could better the lives of thousands of&nbsp;women with&nbsp;ovarian cancer.
SEE MORE&nbsp;<a href="https://www.editorji.com/story/zydus-cadila-gets-us-fda-nod-for-fulvestrant-jab-for-breast-cancer-treatment-1627652665293">Zydus Cadila gets US FDA nod for Fulvestrant jab for breast cancer treatment</a>
Medical trials of a&nbsp;novel&nbsp;drug combination show that the drugs can&nbsp;together&nbsp;shrink tumours in half of&nbsp;the&nbsp;patients with an advanced form of the disease.&nbsp;When used together, the pair of drugs work by blocking the signals that cancer cells need to grow.&nbsp;
Presented&nbsp;at&nbsp;the <a href="https://www.icr.ac.uk/news-archive/drug-combination-shows-promise-in-treatment-resistant-advanced-ovarian-cancer">European Society for Medical Oncology</a> congress, experts have hailed the results to be &lsquo;fantastic&rsquo;, reports The Guardian.&nbsp;&nbsp;
The development could offer a new treatment method for&nbsp;women with a type of ovarian cancer that is unresponsive to chemotherapy or hormone therapy.&nbsp;Called&nbsp;VS-6766 and&nbsp;defactinib, the drug combination&nbsp;was tested in&nbsp;patients with low-grade serous ovarian cancer.&nbsp;
Of the 25 patients assessed in the trial,&nbsp;46% saw their tumours shrink significantly in response to the treatment.&nbsp;Patients with a particular mutation&nbsp;who had&nbsp;KRAS-driven tumours witnessed even better outcomes with 64% seeing tumour shrinkage.
SEE MORE&nbsp;<a href="https://www.editorji.com/story/up-your-fruit-and-veggie-intake-to-lower-breast-cancer-risk-1632109442146">Up your fruit and veggie intake to lower breast cancer risk!</a>
The second phase of trials&nbsp;is&nbsp;already underway and the team led by the Institute of&nbsp;Cancer&nbsp;Research (ICR) in London and the Royal Marsden NHS Foundation Trust&nbsp;believes that if the results are repeated in larger&nbsp;trials, it&nbsp;could prove to be a&nbsp;significant advance in low-grade serous ovarian cancer treatment.&nbsp;&nbsp;

With fair representation to Muslims, JD(U) reaches out to community

PTI,&nbsp;Patna:&nbsp;Close to 10 per cent of the JD(U)'s candidates for Bihar Assembly polls are Muslims, a clear message from the party headed by Chief Minister Nitish Kumar that it will continue to protect the interests of the minority community and they have nothing to fear despite its realignment with the new and aggressive BJP.&nbsp;
 Under the seat-sharing arrangement of the NDA, the JD (U) has got 122 out of the total 243 constituencies in the state and it will be contesting 115, leaving aside seven for ex-chief minister&nbsp;Jitan&nbsp;Ram Manjhi's Hindustani&nbsp;Awam&nbsp;Morcha&nbsp;(HAM) which has returned to the NDA.&nbsp;
The party has announced its nominees for all 115 seats, of whom 11 are Muslims. This figure of close to 10 per cent is less than commensurate with their population in the state where they comprise more than 15 per cent of the populace.&nbsp;
Nonetheless, with a steady decline in the community's electoral representation over the decades, the JD(U) may end up claiming that it scored better than most on this count.&nbsp;
In the 2015 Assembly polls, which the JD(U) had contested in alliance with the RJD and the Congress, five of the party's candidates had emerged victorious.&nbsp; Four of them are again in the fray from their respective seats Khurshid alias Firoz Ahmed (Sikta), Sharfuddin (Sheohar), Naushad&nbsp;Alam&nbsp;(Thakurganj) and Mujahid&nbsp;Alam&nbsp;(Kochadhaman).&nbsp;
The fifth such candidate, Sarfaraz&nbsp;Alam&nbsp;from&nbsp;Jokihat, had quit the party in 2018 and joined the RJD which fielded him as its candidate from&nbsp;Araria&nbsp;Lok Sabha seat in a by-poll necessitated by the death of his father Mohd&nbsp;Taslimuddin, a powerful though controversial politician of the Kosi belt.&nbsp; Alam&nbsp;won the seat but lost it to the BJP in the general elections the following year. Earlier, his brother Shahnawaz&nbsp;Alam&nbsp;had succeeded in wresting&nbsp;Jokihat&nbsp;from the JD(U).&nbsp;
In the upcoming polls,&nbsp;Jokihat&nbsp;has fallen into the BJP's kitty.
The JD(U) will be trying its luck in the adjoining&nbsp;Araria&nbsp;where it has fielded Shagufta Azim. The seat was won, in 2015, by the Congress.&nbsp;
Besides Azim, two other women&nbsp;figure&nbsp;among the party's Muslim candidates. Asma Parveen, daughter of senior RJD leader Ilyas Hussain, has been fielded from Mahua which is the constituency of Lalu Prasad's elder son Tej Pratap Yadav.&nbsp;
Hussain had won from&nbsp;Dehri&nbsp;on an RJD ticket in 2015 but got disqualified a few years later following his conviction in the bitumen scam. His son Firoz made an unsuccessful bid to retain the seat for the RJD in a by-poll held last year and joined the JD(U) less than a month ago.&nbsp;
The JD(U) has sprung a surprise in Dumraon where it has dropped Dadan&nbsp;Pahalwan, a local muscleman who is its sitting MLA. The party nominee this time is Anjum Ara, who is known in the media circles by virtue of being a party spokesperson. It remains to be seen if she can hold her own in the rough and tumble of electoral politics.&nbsp;
Realizing the tough&nbsp;challenge&nbsp;it faces this time for securing Muslim votes, the JD(U) has also accommodated rebels from the RJD like Faraz Fatmi, the MLA from&nbsp;Keoti&nbsp;whom it is fielding from Darbhanga Rural.&nbsp;
Fatmi's father MAA Fatmi was an RJD veteran and former Union minister who had quit the party during Lok Sabha polls, upset over alleged peremptory&nbsp;behaviour&nbsp;of&nbsp;Tejashwi&nbsp;Yadav.&nbsp;
MAA Fatmi had joined the JD(U) many months ago,&nbsp;signalling&nbsp;the son's likely trajectory.&nbsp;
The JD(U) has, despite its alliance with the BJP, succeeded in winning over a section of Muslims by virtue of measures like reservations to the&nbsp;Pasmanda&nbsp;group, scholarships to students from the minority community including those receiving their education at madrasas.&nbsp;
The community has been restive over the party's equivocal stance on the CAA which it ended up voting for in the Parliament. Nonetheless, the wily chief minister got the BJP to back a resolution passed unanimously by the assembly opposing the proposed NRC.&nbsp;
People also acknowledge Nitish Kumar's role in keeping communal flare-ups under check, the most recent example being in 2018 when several minor clashes broke out around Ram Navami in a number of districts but none of these was allowed to snowball into a major riot.&nbsp; &nbsp;

Close to 10 per cent of the JD(U)'s candidates for Bihar Assembly polls are Muslims, a clear message from Nitish&nbsp;Kumar's party that it will continue to protect the interests of the minority community and they have nothing to fear despite its realignment with the aggressive BJP. The party has announced its nominees for all 115 seats, of whom 11 are Muslims. In the 2015 Assembly polls, which the JD(U) had contested in alliance with the RJD and the Congress, five of the party's Muslim candidates had emerged victorious. Analysts say the&nbsp;JD(U) has, despite its alliance with the BJP, succeeded in winning over a section of Muslims by virtue of measures like reservations to the&nbsp;Pasmanda&nbsp;group, scholarships to students from the minority community including those receiving their education at madrasas.&nbsp;

PTI,&nbsp;Patna:&nbsp;Close to 10 per cent of the JD(U)'s candidates for Bihar Assembly polls are Muslims, a clear message from the party headed by Chief Minister Nitish Kumar that it will continue to protect the interests of the minority community and they have nothing to fear despite its realignment with the new and aggressive BJP.&nbsp;
 Under the seat-sharing arrangement of the NDA, the JD (U) has got 122 out of the total 243 constituencies in the state and it will be contesting 115, leaving aside seven for ex-chief minister&nbsp;Jitan&nbsp;Ram Manjhi's Hindustani&nbsp;Awam&nbsp;Morcha&nbsp;(HAM) which has returned to the NDA.&nbsp;
The party has announced its nominees for all 115 seats, of whom 11 are Muslims. This figure of close to 10 per cent is less than commensurate with their population in the state where they comprise more than 15 per cent of the populace.&nbsp;
Nonetheless, with a steady decline in the community's electoral representation over the decades, the JD(U) may end up claiming that it scored better than most on this count.&nbsp;
In the 2015 Assembly polls, which the JD(U) had contested in alliance with the RJD and the Congress, five of the party's candidates had emerged victorious.&nbsp; Four of them are again in the fray from their respective seats Khurshid alias Firoz Ahmed (Sikta), Sharfuddin (Sheohar), Naushad&nbsp;Alam&nbsp;(Thakurganj) and Mujahid&nbsp;Alam&nbsp;(Kochadhaman).&nbsp;
The fifth such candidate, Sarfaraz&nbsp;Alam&nbsp;from&nbsp;Jokihat, had quit the party in 2018 and joined the RJD which fielded him as its candidate from&nbsp;Araria&nbsp;Lok Sabha seat in a by-poll necessitated by the death of his father Mohd&nbsp;Taslimuddin, a powerful though controversial politician of the Kosi belt.&nbsp; Alam&nbsp;won the seat but lost it to the BJP in the general elections the following year. Earlier, his brother Shahnawaz&nbsp;Alam&nbsp;had succeeded in wresting&nbsp;Jokihat&nbsp;from the JD(U).&nbsp;
In the upcoming polls,&nbsp;Jokihat&nbsp;has fallen into the BJP's kitty.
The JD(U) will be trying its luck in the adjoining&nbsp;Araria&nbsp;where it has fielded Shagufta Azim. The seat was won, in 2015, by the Congress.&nbsp;
Besides Azim, two other women&nbsp;figure&nbsp;among the party's Muslim candidates. Asma Parveen, daughter of senior RJD leader Ilyas Hussain, has been fielded from Mahua which is the constituency of Lalu Prasad's elder son Tej Pratap Yadav.&nbsp;
Hussain had won from&nbsp;Dehri&nbsp;on an RJD ticket in 2015 but got disqualified a few years later following his conviction in the bitumen scam. His son Firoz made an unsuccessful bid to retain the seat for the RJD in a by-poll held last year and joined the JD(U) less than a month ago.&nbsp;
The JD(U) has sprung a surprise in Dumraon where it has dropped Dadan&nbsp;Pahalwan, a local muscleman who is its sitting MLA. The party nominee this time is Anjum Ara, who is known in the media circles by virtue of being a party spokesperson. It remains to be seen if she can hold her own in the rough and tumble of electoral politics.&nbsp;
Realizing the tough&nbsp;challenge&nbsp;it faces this time for securing Muslim votes, the JD(U) has also accommodated rebels from the RJD like Faraz Fatmi, the MLA from&nbsp;Keoti&nbsp;whom it is fielding from Darbhanga Rural.&nbsp;
Fatmi's father MAA Fatmi was an RJD veteran and former Union minister who had quit the party during Lok Sabha polls, upset over alleged peremptory&nbsp;behaviour&nbsp;of&nbsp;Tejashwi&nbsp;Yadav.&nbsp;
MAA Fatmi had joined the JD(U) many months ago,&nbsp;signalling&nbsp;the son's likely trajectory.&nbsp;
The JD(U) has, despite its alliance with the BJP, succeeded in winning over a section of Muslims by virtue of measures like reservations to the&nbsp;Pasmanda&nbsp;group, scholarships to students from the minority community including those receiving their education at madrasas.&nbsp;
The community has been restive over the party's equivocal stance on the CAA which it ended up voting for in the Parliament. Nonetheless, the wily chief minister got the BJP to back a resolution passed unanimously by the assembly opposing the proposed NRC.&nbsp;
People also acknowledge Nitish Kumar's role in keeping communal flare-ups under check, the most recent example being in 2018 when several minor clashes broke out around Ram Navami in a number of districts but none of these was allowed to snowball into a major riot.&nbsp; &nbsp;

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