A US government-led study published in the Journal of the American Medical Association has found no link between ovarian cancer and the use of talcum powder. The research is based on data from over 250,000 women and four large studies. Although the study is the largest of its kind, the authors said there were several limitations. Professor Kevin McConway from Britain's Open University called it a "good study" but added that it could not rule out a link between talc and cancer entirely. The research establishes that if such a risk does exist, it is likely to be very small. In 2018, US pharmaceutical giant Johnson & Johnson was ordered to pay $4.7 billion to 22 women who claimed that asbestos in its products caused ovarian cancer. An appeal is underway.