Real Madrid and Bayern Munich were among the clubs to qualify for the last 16 of the Champions League with two group games to spare on Wednesday, while Manchester United's poor form continued as they slipped to a stunning 4-3 defeat against FC Copenhagen.
United led 2-0 in the Group A game before Marcus Rashford was sent off late in the first half, and later threw away a 3-2 lead as Roony Bardghji got the Danish side's late winner.
Last season's runners-up Inter Milan and Real Sociedad also secured their tickets for the knockout phase, joining holders Manchester City and RB Leipzig in advancing to the last 16.
Madrid, the record 14-time European champions, made sure of their progress from Group C with a 3-0 home win over Braga after surviving an injury setback just before kick-off.
Bayern qualified with a 2-1 victory at home to Galatasaray, their 17th consecutive win in the Champions League group stage.
Thomas Tuchel's side saw Galatasaray have a goal disallowed for offside before Harry Kane headed in the opener with just 10 minutes left.
Kane then added another, his 19th goal already for Bayern in just 15 appearances.
Meanwhile, Arsenal are on the brink of progressing from Group B after a 2-0 home win over Sevilla, in which Bukayo Saka set up Leandro Trossard for the opener in the first half, and then added the second after the break.